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Most of them were involved in the subtle changes of the biochemical properties of its surrounding structure, whereas there were 54 residues located within the structurally and/or functionally important sites (Table 1).
Thus, it is not unexpected that there are antibody epitopes incorporating EDII fusion peptide residues and residues within the structurally adjacent EDIII of the alternate monomer.
However, A. niger P43 sequence has two insertions (one of 4 residues and another of 9 residues) within the structurally conserved tRNA binding domain.
Dihedral angle analysis indicates that all residues within the structurally ordered region (residues 10 84) of N- HvGR-RBP1 have ϕ and ψ dihedral angle values that are within the allowed ranges of the Ramachandran plot.
The p.Y793H variant that was suggested to be a 'potentially damaging' substitution with high probability on the other hand (Functionality score = 6; Table 1) is largely buried within the structurally and functionally important αV4 helix (23) in the VPS9 domain.
A number of these interactions occur within the structurally conserved domains of MTA1, but others are directed through intrinsically disordered regions that become ordered on binding and are key to forming a stable NuRD complex.
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Within the structurally-confined internal aqueous cavity of the F1-motor of ATP synthase, function results from free energy changes that shift the balance between interfacial charge hydration and interfacial hydrophobic hydration.
First, it can identify breakpoints in both unique and repetitive genomic regions which allows us to assess structural variant (SV) within the most structurally dynamic parts of the genome, namely at transposons and low copy repeats (LCRs).
Multiple pair-wise superpositions of homologues within each CATH superfamily, revealing the structurally conserved core, can be seen on the CATH website.
Within this module, there is the structurally similar (and possibly related) PGBD-like domain, which has a general peptidoglycan binding function, together with the Blood coagulation inhibition domain, Leukotricene A4 hydrolase domain and Hemopexin-like domain.
The structurally controlled instabilities within the tunnel sections were identified and the required preliminary tunnel support systems were determined to overcome these instabilities.
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