Moreover, there is significant activation of CD8+ T cells within the granuloma [10] despite the sequestration of the Mtb within a phagosome and away from the class I antigen processing pathway.
The overexpression of Ex5-MBNL1 42–43 inoforms in the muscle from DM1 patients, ensuring their restrictive nuclear localization, indicates an important feature for the sequestration within the foci.
However, doxorubicin distribution may not provide a 'global' or typical template for drug distribution due to the sequestration within the outer cell population caused by its avid binding to cellular macromolecules (Sutherland et al, 1979; Kwok and Twentyman, 1985; Tunggal et al, 1999).
However, disadvantages of this approach include excessive sebum within the follicle, sequestration of drug within the follicle, and lack of appendages in some areas of the body [40].
The sequestration of lymphocytes within the priming sites was also confirmed by the higher count of TgN T cells retained in draining lymph nodes of FTY720-treated mice compared to control.
Furthermore, the higher percentages of proliferating T cells observed in cervical and mediastinal lymph nodes of FTY720-treated versus untreated mice, corresponded to a higher absolute number of TgN CD4+ and CD8+ T cells present in the draining lymph nodes, thus confirming the sequestration of lymphocytes within the priming sites.
Under normal physiological conditions leading to MIA biosynthesis, the sequestration of strictosidine biosynthesis within the vacuole and its subsequent deglucosylation within the nucleus by a stable supramolecular SGD complex implies that an unknown transportation system of strictosidine across the tonoplast plays an important role in the control of the MIA biosynthetic flux.
Impaired T cell-mediated immunity in such patients could be due to the sequestration of T cells within organs affected by sarcoid, such as the lung.
Microautophagy also involves the sequestration of cellular constituents within lysosomes but in this case through the invagination of the lysosomal membrane.
The sequestration of hnRNP K within these aggregates is suggested to result in an increase in translocation of PKCδ to the mitochondria, resulting in induction of apoptosis (17).
