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Study strengths include its nesting within the randomized controlled WHI clinical trial, implying randomization assignments that are known and that are statistically independent of genotype and the related ability to use case-only analyses for intervention testing.
Within the randomized controlled experiment conducted by Inventado et al. (2016), the treatment group was able to request a series of progressive hints, while the control group was only able to access a bottom-out hint (one which provides the answer).
Each random group was given only one modality either 2D+, 3D or 3Dr and was tested within the randomized modality.
This study examined these survey and medical record variables as a secondary, observational analysis nested within the randomized trial.
Adjuvant hormone therapy was not utilized within the randomized clinical trials and infrequently employed for out-trial patients, as it was not considered mandatory at that time.
We reviewed 205 tumor samples of patients with locally advanced bladder cancer mainly treated within the randomized AUO-AB05/95 AUO-AB05/95radical cystrialmy and adjuvant cisplatin-based chemotherapy for histologic subtypes.
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Within stratum the randomized groups were well matched, but the background metformin stratum was younger, more overweight and had shorter duration of diabetes than the sulfonylurea stratum.
Data obtained from the four experiments performed under different environmental conditions showed significant correlations (Table S1), and within each experiment, the randomized blocks were significantly correlated with R2 values varying from 0.57 to 0.76 (data not shown).
https://doi.org/10.1007/s00277-012-1650-8. Saussele S, Lauseker M, Gratwohl A, Beelen DW, Bunjes D, Schwerdtfeger R, et al. Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV.
These models provided estimates adjusted for the heterogeneity between studies and the correlation within studies given by the randomized studies with more than two groups.
Within the context of the randomized trial we used qualitative methods to explore the difficulties experienced by lay-workers, women and health professionals involved in the peer-mentoring programme.
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