Proliferation in the progenitor/stem cell niches depends on Cdk4 activity, being carefully downregulated within the niche and increasing when the progenitor cell enters in the so-called transit-amplifying state to become differentiated [47].
Next, we showed that once the tumor cells populate the metastatic niches (bones and lungs), they further increase the mast cell population within the niche and assist in enhancing metastasis.
And custom boots are a niche within the niche.
The process of divergence within the niche then begins anew.
In a sense, then, the Neon R/T occupies a niche within the niche.
One wonders, though, whether the ethical startup will always sit within the niche category or, worse, be squeezed out of business by the sheer might of its competitors.
But the market for homes at the very top of the range, what the industry calls "super prime," is more buoyant than ever — and within the niche, historic property is in high demand.
What Germans know as Lieder – is a niche product, even within the niche that is classical music; but Winter Journey is an indispensable work of art that should be as much a part of our common experience as the poetry of Shakespeare and Dante, the paintings of Van Gogh and Picasso, the novels of the Brontë sisters or Marcel Proust.
Though like yougo, survivors may need to find a 'niche within the niche'.
Loss of Abd-B is associated with cell non-autonomous effects within the niche, leading to a dramatic reduction of pre-meiotic cell populations in adult testes.
However, the number of parameters at play, and their complex interactions, presents a formidable challenge in delineating how the decisions of cell fate are orchestrated within the niche.
