Within the microenvironment, the extracellular matrix (ECM) is an important support structure that provides dynamic signaling cues in part through its chemical, physical, and mechanical properties.
The canonical pathways that were affected are involved in inter- and intra-cellular communication, regulating signaling within the microenvironment.
It is driven by intercellular adhesions, cell contractility, and forces generated within the microenvironment and is dependent on extracellular matrix composition, organization, and compliance.
Tumors exist within a complex tumor microenvironment that develops during the course of disease, but very little is known about how the microenvironment develops, or how the cells within the microenvironment impact the outcome of disease.
Biochemical components within the microenvironment, including growth factors and cytokines, have well-established functions in regulating cell behavior, and some success has been achieved recapitulating these biochemical signals within scaffold microenvironments.
Herein, we present an in vivo study of [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) designed to evaluate the metabolism within the microenvironment of LAPC4-CR, a unique murine model of castration-resistant prostate cancer.
This chapter discusses the details of this important approach, which aims to improve the survival of transplanted cellular products by sustained oxygen delivery within the microenvironment of tissue-engineered sites.
Enhanced understanding of the signals within the microenvironment that regulate cell fate has led to the development of increasingly sophisticated polymeric biomaterials for tissue engineering and regenerative medicine applications.
This approach offers an effective therapeutic strategy to reduce tendon adhesions by directly targeting the down-regulation of COX-1 and COX-2 expression within the microenvironment of the injured tendon.
This result demonstrates the merit of bacteria as cancer drug delivery vehicles to administer cancer-starving proteins such as L-ASNase to be effective selectively within the microenvironment of cancer tissue.
The expression of the receptor was reduced by different signals that leukemic cells may encounter within the microenvironment of lymphoid tissues (Borge et al., 2014).
