The NICE recommendations for treatment differ considerably from the information provided within the Indications for Treatment, Contraindications and Special Warnings and Precautions for Use sections in the SPCs.
Given the low rate of complication with short-term therapeutic hypothermia and the published beneficial effects [ 1, 2, 5], therapeutic hypothermia should be a standard treatment within the indications recommended by published guidelines and each hospital should generate or adopt written SOP for the indication and clinical use of therapeutic hypothermia [ 3].
Among these patients, 10 were excluded because of liver failure, 44 underwent hepatectomy before IFN- α/5-FU combination therapy because they were within the indications for operation, 15 received other treatments, seven had distant metastases, four were over 75 years of age, and four patients refused to sign the informed consent form because of fear of adverse effects.
Within the hand the indication for compound VBGs is dominated by thumb reconstruction (skin and bone grafts).
A company can test individual drugs for second targets within the same indication or find a second indication for the drug.
As regards the follow-up of the children who had multiple ED accesses for headache, 32 patients who had repeated visits within 3 months received the indication to refer to the PHC; 24 of them were actually followed-up, and only 1 of them accessed the ED again because of headache after starting the follow-up.
Therefore, the potential role of degarelix within a discussion about the indication for androgen deprivation therapy with regard to efficacy, adverse events, and costs remains unclear and could be limited.
The efficacy of memantine was consistently demonstrated versus placebo across the cognition, ADL, and overall assessment domains within the licensed indication.
For example, a new innovative drug may be limited within the registered indication, but the risk of off-label use still exists.
