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It was assumed that T-epitopes on adalimumab only reside within the complementarity determining region (CDR): adalimumab is a fully human antibody, thus other regions would be conceivably well tolerated by the immune system.
The two latter clones were also obtained from the DBA/1-Vβ12-tg mouse and share both TCR α-chains and β-chains with 22a1-7E, but differ at one single amino acid within the complementarity determining region 3 (CDregiongiof of the nontransgenic Vα chain (RB, unpublished data).
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We used a high-throughput nonspecificity assay to isolate panels of nonspecific antibodies from two synthetic single-chain variable fragment libraries expressed on the surface of yeast, identifying both individual amino acids and motifs within the complementarity-determining regions which contribute to the phenotype.
In the case of the 40-kDa fragment, cleavage occurred within the complementarity-determining region (CDR) H3 loop of the VH domain, yielding predominantly G as N-terminal amino acid (TLF↓GVPIA).
The alphabet of DNA is with the complementarity relation and.
According to this model, a nascent DNA strand transiently dissociates from a template strand, and, due to the complementarity within a microsatellite sequence, strand misalignment upon reassociation occurs with an increased probability.
When incorporating the complementarity of species within the return on investment framework, our objective is to protect as many different, or 'distinct', species as possible.
All are guided by the complementarity determining regions (CDRs) within variable fragment domains targeting human epidermal growth factor receptor 2 (HER-2) Fig. 1.
The mean ' C jk ' for all possible comparisons within each mesocosm was calculated and presented as the complementarity score (C).
More importantly, the complementarity of the systemic and parametric reforms holds even in the setting of within-cohort heterogeneity.
He stressed the complementarity between community and clinical medicine.
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