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Several investigations have suggested that the GC nucleotides within the ARE are essential for both the basal and oxidative stress induced activities of the ARE-related genes, NAD(P H dehydrogenase quinone 1 (NQO1) and glutamate-cysteine ligase catalytic subunit (GCLC) (Wasserman and Fahl 1997; Wild et al. 1998).
A 26-nucleotide sequence within the ARE is conserved among species and is both necessary and sufficient for protein binding and the regulation of PTH mRNA stability by dietary calcium or phosphorus depletion [ 16, 17].
This was comparable to a 55.5 % virus detection proportion in the throat swabs obtained within the "ARE surveillance Lower Saxony" (two-sample test of proportions, p = 0.264, Fig. 2).
In 64.3 % of the symptom-triggered nasal swabs, respiratory viruses were found compared to 55.5 % in throat swabs taken by health-care professionals within the "ARE surveillance Lower Saxony", a special project by the Governmental Institute of Public Health of Lower Saxony to investigate causal pathogens for acute respiratory infections in children.
Robust promoter activity in NSCLC lines was mediated by a 359 bp segment of the proximal promoter that contained a canonical AP-1 binding site, TGACTCAG, within the ARE.
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