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The present task not only removes the navigational requirement but also reduces the need for the animal to monitor where it has travelled within that trial.
In an EORTC trial of temozolomide in the primary treatment of glioblastoma [ 1] MGMT methylation status was strongly prognostic for survival, and with a suggestion of a predictive effect [ 2] although this remains unproven within that trial.
The third derivative of the transverse plane rotation of the pelvis disk/sensor measured during each trial was used to estimate the start of each gait cycle within that trial.
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Wilcoxon signed-rank tests between trials within the same session demonstrated that trials in session 1 were significantly different and in the subsequent 3 sessions, the median differences between trials were not significantly different.
Wilcoxon signed-rank tests between trials within the same session demonstrated that trials in session 1 were significantly different (p < 0.01) with a median difference of 0.78 seconds (− 0.06 m/s; Table 2).
Parents and children need to know that they will be kept informed of any significant developments within the trial that may affect safety.
One should note that within this trial two therapeutic strategies are compared rather than two specific therapies with the aim to increase external validity and ensure feasibility.
Post hoc analysis of the significant group×risk×time interaction effect indicated that within the trial group, perceived risk decreased significantly in women at low risk (t(49)=6.90, P<0.001) and moderate risk (t(221)=11.83, P<0.001).
The very large size of the trial population meant that it would have been impractical to collect and analyse detailed (and largely qualitative) information on variations in assessment practices; by the same token it is likely that within the trial there was a range of assessment models, some of which will have existed outside the sites as well.
In an adaptive clinical trial (ACT), key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself.
Conditional estimates should not be compared to unconditional estimates since estimates from a series trial are correct only within the context of that trial.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com