Suggestions(1)
Exact(2)
The following PK parameters were determined, either by direct observation or by noncompartmental analysis (WinNonlin, version 5.0.1; Pharsight, Mountain View, CA, USA): the minimal plasma concentration (Cmin), the maximal plasma concentration (Cmax), the area under the curve within one dosing interval (AUC0− τ ) and total plasma clearance (Cl/F).
The estimated PK parameters for AZD3409 ester and AZD3409 acid at all dose levels are presented in Table 3. Extrapolation of the AUC of AZD3409 ester and AZD3409 acid to infinity exceeded 20% in most cases and therefore AUC values within one dosing interval (AUC0− τ ) were reported.
Similar(58)
Different regions of the stomach had different damage levels, which were not consistent within one dose group.
The plasma concentrations at 1 h were higher in COPD patients compared to those in healthy subjects; however the levels were within one doubling dose (assuming dose linearity).
The "relationship between dose and clinical outcome" for beta-lactams also is unpredictable (criterion 5) due to the variability in clinical response both between and within patients from one dose to the next.
The " relationship between dose and clinical outcome" for beta-lactams also is unpredictable (criterion 5) due to the variability in clinical response both between and within patients from one dose to the next.
However, when comparing across hospitals, we found that within one hospital dose levels can be in the high or low range depending on the CT region studied.
Differences between delta values within one session (dose dependent effect) were analyzed using two-way repeated measures ANOVA with the stimulus intensity as within-participant factor and gender as between-participant factor.
Prescribed dosage was one dose within 12 hours before sex, one dose within 12 hours after sex, and no more than two doses in 24 hours (Abdool Karim et al., 2010).
For imaging studies, mice were implanted as previously described using a dual flank model, and after 17 days animals were selected for imaging based on having paired size-matched tumours of 300 mm (within 25%) before receiving one dose of dox prepared as described above.
In the VASST analysis, the use of corticosteroids was regarded as receipt of at least one dose within the 28-day observation period, whereas the current study ensured corticosteroids were used concomitantly with AVP.
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