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Pyrosequencing de-noising algorithms such as Pyronoise [29] aim to reduce this by within-dataset analysis, but are computationally costly.
Two-tailed t-tests were used for within-dataset comparisons of PKC-β gene expression in different lymphoma subtypes.
The overall process of the within-dataset experiment is illustrated in Fig. 2A.
The process for selecting the feature set was similar to the one used in the within-dataset experiments.
To compare the proposed method with other existing methods, we performed the described within-dataset experiments and the cross-dataset experiments using other pathway activity inference methods (mean, median, PCA, and CORG).
The proposed classification method yielded the highest classification accuracy in both within-dataset experiments, and it also outperformed other methods in cross-dataset experiments, with the only exception of the mean-based inference method in one of the experiments.
These are shocking statistics and the over-representation of Asian offenders within this dataset certainly merits attention.
First, cross-validation analyses were conducted within the dataset.
Worksheet 3 reports the samples within our dataset that bear homozygous losses in each gene.
Observer error was small compared to the variation within the dataset.
The proportion of Finn-characteristic haplogroups within each dataset used19,20,21,22,23,24 varied between 20.2 45.3% (Supplementary Table S6).
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