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Minor haplotypes whose frequencies were less than 5%% were removed from the calculations and all of the markers were reasonably within Hardy-Weinberg equilibrium (HWE, P>0.002 for either high or low).
The observed allele frequencies for all SNPs, except for 5237A>G among women (p = 0.03) and 4741G>C among men (p = 0.001), were within Hardy-Weinberg equilibrium among the controls.
Genotype distributions were within Hardy-Weinberg equilibrium (data not shown).
All cohorts, however, demonstrated genotype frequencies within Hardy-Weinberg Equilibrium (HWE).
The distribution is within Hardy-Weinberg equilibrium (X=0.64, p=0.42).
This, however, may be an effect of the extreme rarity of the TT genotype, as both populations are within Hardy-Weinberg equilibrium for all other SNPs, indicating little or no selection bias for these SNPs.
A total of 554 patients were evaluated and genotyped for 10 SNP markers, and five of these markers were excluded due to failure to fall within Hardy-Weinberg equilibrium or to monomorphism.
Five hundred fifty-four patients were evaluated and genotyped for 10 single-nucleotide polymorphism (SNP) markers, but 5 of these markers were excluded due to failure to fall within Hardy-Weinberg equilibrium or to monomorphism.
In analyzing the allelic frequency of the polymorphisms rs12979860 and rs8099917 within the IL-28B gene, both HBV cases and controls were within the Hardy-Weinberg equilibrium (P > 0.05).
All 9 SNPs were within expected Hardy-Weinberg proportions in both cases and controls (Table 2).
The genotypic frequencies in these SNPs in controls were within the Hardy-Weinberg expectations.
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