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Correlation between freezing within extinction and the number of faecal boli or c-Fos-positive cells was performed by using Spearman's coefficient test.
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During the extinction session, IL neurons showed within-extinction decreases in CS-evoked activity that paralleled within-session decreases in freezing and they showed different levels of CS-evoked firing during the retention test that reflected different levels of freezing to the CS during the test.
They propose that differences in physiology among taxa may account for the differences in within-continent extinction probability.
Within-session extinction.
The fear responses exhibited in the presence of CS are reduced (i.e., extinguished) over the course of exposure to CS alone (within- session extinction) [ 68].
Similarly, Fendt et al. (2009) reported facilitated within-session extinction of conditioned freezing after infusion of NPY into the amygdala in mice.
In Y1/Y2 receptor double KO mice, however, within-session extinction was significantly delayed, while between-session extinction was entirely absent, suggesting a crucial role of Y2 receptors in the consolidation of fear extinction.
Along similar lines, low freezing responses observed in a within-session extinction trial were accompanied by enhanced c-Fos response in mPFC areas including the IL (Morrow et al., 1999).
Within-session extinction was determined by (i) the change of the freezing response over the course of consecutive CS presentations on extinction day 1; and (ii) by comparison of the first three CS with the last three CS on each extinction day.
NPY KO mice did not only display significantly impaired within-session extinction, but also impaired between-session extinction, shown by comparing % freezing upon the first CS+ on three consecutive days= 71.71, P < 0.0001; time: F(1/25)= 3.49, P < 0.05 and interaction genotype × time: F(2/50)= 4.92, P < 0.05).
The purpose is to assess the role played by humans within the extinction process of Pleistocene mammals in the South Cone and the effects that the disappearance of Pleistocene large mammals had in human populations which colonized both regions.
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