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The concentrations of LBH589 used in our study that downregulate c-FLIP and enhance TRAIL-induced apoptosis are between 12.5 nM and 100 nM and thus within clinically achievable range.
Ensure that this note is within an achievable range.
Thus, the effective 4‑HNE concentration was likely on the order of 1 μM, well within a physiologically achievable range (low micromolar; 5).
Based on the literature, the concentrations of CS used in these experiments are comparable to those suggested to be within a physiologically achievable range [ 18, 19].
These drug concentrations were estimated to fall within a clinically achievable range (Hidalgo et al, 2001; Pegram et al, 2004), and showed activity in preliminary dose response studies (see Supplementary Figure 2S).
The achievable range of frequency was 1 500 droplets/sec.
Therefore, the dose at which tumor cell line growth declines is in a physiologically achievable range.
The concentrations we used in this study model are close to a normal physiologically achievable range [ 33, 34].
A vehicle's antenna obtains signals from all senders within its maximum achievable communication range with radius d range comm.
Thus the concentrations used in this study are within the range achievable in human plasma.
Therefore, the EC50 for cell viability of 60 μM (22 μg/mL) obtained in this study is within the range achievable in vivo, assuming average tissue densities of about 1.06 g/mL.
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