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Eight (22.9%) patients were treated on first rTKI therapy within prospective trials, and 17 (48.6%) patients were at least once treated within a prospective trial.
In this retrospective analysis within a prospective trial, we evaluated the association between UGT1A genotypes/haplotypes and TYMS genotypes and toxicity (severe toxicity at first cycle and at the end of treatment), response rate, time to progression (TTP) and overall survival (OS).
We have recently demonstrated within a prospective trial (RELAZA1 study) that minimal residual disease (MRD -triggered pre-emptive treatment with azacytidine (AZA) is able to prevent or at least delay hematologic relapse in patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT).
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This service model would need to be exposed to a proper resource utilization analysis within a prospective trial-setting designed to establish the true value/resource implication of a restructured service that embraces this intervention.
A prospective trial to validate these thresholds is needed.
This was a prospective trial of diagnostic accuracy.
A prospective trial of tacrolimus immunosuppression with percutaneous biopsy.
Profiling Remicade Onset with MTX in a Prospective Trial,.
Tumour samples and corresponding data may come from patients treated within a prospective (randomised) trial, or they may come from those not taking part in a trial.
The current AML-CG 2008 study was initiated to confirm these results and to compare the efficacy and toxicity of S-HAM with standard double induction within a prospective randomized trial using the overall response rate (ORR) as the primary endpoint.
One of the first attempts to explore the role of pathology review within a prospective clinical trial on high grade glioma was done within an RTOG study [ 28].
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CEO of Professional Science Editing for Scientists @ prosciediting.com