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A good linear correlation between doses of drugs and number of mice with place preference was found within a given dose range.
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Anecdotal and accidental random events where variable concentrations of Cu was related to acute gastrointestinal symptoms have appeared in the literature (National Research Council 2000; Ross 1955; Spitalny et al. 1984; Wyllie 1957), but the exact responses and their distribution at a given dose within a population were unknown.
The literature suggests the treatment effects of a given dose are observed within a day after initial administration [ 53].
With food allergens, both the nature and the severity of the response to a given dose vary considerably even within the susceptible subpopulation.
But the patents cover the process for determining whether a given dose produces concentrations of metabolites within a recommended range.
The index k is from 1 to K number of treatments within a group (i.e., corresponding to a given chemical, a treatment is exposure to a given dose at a given time point).
Similar to the specificity of inhibition of LY294002 (within the given dose range) on PI-3K, there was a PD98059-dose-dependent inhibition of MEK activity, as demonstrated by reduced phosphorylation of MAPK by Western blot analysis with MAPK threonine-202 phosphorylation-specific antibodies.
In contrast, within the given dose range of LY294002, there was no effect of LY294002 on the activity of the MEK/MAPK pathway; the Ras-induced increase in MEK/MAPK activity was unchanged, indicating the relative specificity of LY294002 in our experimental system in inhibiting the PI-3K/Akt pathway.
Moreover, within a given individual, the threshold dose can vary over time.
Galm et al. [ 12] had demonstrated the application of ERMA technique for the quantitative analysis of methylaiton density, in which KG1a cells were treated in vitro with the increasing 5'aza-2'-deoxycytidine (DAC) dose within a given time course.
(Within a given data set, the highest nonsignificant dose was regarded as the NOAEL for that data set).
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