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Comparative effectiveness research designs may best capture TMB treatment complexity, especially pragmatic trials and similar practice-based research methods that replicate daily practice within a controlled framework [ 25, 26].
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To date, no research appears to have used a pharmacological probe within a controlled experimental framework to assess neurochemical processes underlying problem gambling.
Would Bolivia become a mixed economy, accepting corporate participation when desirable, but within a state-controlled framework, like China?
However, no previous study has examined the effect of weight loss on migraine within a treatment-controlled framework.
Watching "Gilbert Grape," in which DiCaprio played a mentally disabled boy, viewers who knew nothing of him assumed that he truly was mentally disabled; it is hard to imagine another actor who could have behaved so out of control, especially within the strin-gently controlled framework of a Hollywood film.
DESIGN Prospective cohort study within a controlled clinical trial.
It's a stupidly simple solution, really – just plug a bunch of existing machines into a new remote-controlled framework.
A critical part of this process was establishing whether it was feasible and ethical to implement a meaningful intervention within a randomised controlled trial (RCT) framework; key to gaining acceptance for the study was assuring stakeholders that the control arm would receive 'usual care' and that there was a prima facie case for equipoise.
The semistructured nature of the MEDIC-treatment enables individualisation of the treatment within the possibilities of a randomised controlled trial framework.
Thirdly, the treatment of the participants in this study following the preliminary assessment will be individualised within the possibilities of a randomised controlled trial framework.
For each framework, a controlled evaluation was performed as well as one using the framework's internal evaluation methods.
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