Sentence examples for within a candidate interval from inspiring English sources
Researchers can select which information for the genes within a candidate interval or for single genes shall be displayed.
This limitation also leads to false positives arising if genes within a candidate interval are specifically expressed in the BP of interest but do not contribute to disease.
While some researchers prefer to read the available information for all genes within a candidate interval, others may rather narrow down the number of genes beforehand and focus on those fulfilling certain conditions that are regarded as mandatory.
For line M2, we found two potential causal variants in genes that lay 0.63 Mb apart within the candidate interval: a T-to-C transition in Inpp5e and a C-to-A transversion in Slc2a6.
Within the X5 candidate interval, we found a G-to-A transition in Rbm12 and a T-to-A transversion in Dusp15.
This thorough annotation strategy was performed in an attempt to exhaustively clone and characterize all the transcripts within the candidate interval, including those that may be novel, expressed at a low-level or restricted to a specific tissue.
We found resources such as ensembl, UCSC genome server and the NCBI map viewer invaluable, each providing a good overview of biologically relevant data within the candidate interval.
Using these settings, the selected data would be shown for all genes within the candidate interval.
Despite these limitations, in the majority of retrospective cases presented here (including AHI1), UGET analysis rank ordered candidate genes such that sequentially sequencing the most highly correlated genes would identify the known disease gene more far efficiently than sequencing all genes within the candidate interval.
Within the candidate interval, no known genes associated with EDS were present.
All pseudogenes within the candidate interval represented processed pseudogenes, which are thought to arise by genomic integration of cDNA sequences generated by reverse transcription of an RNA transcript.
