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This belief is not shared by a majority in the UK, where 39% believe drugs/treatments are often withheld (table 1).
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To mitigate irAEs, the US prescribing information Risk Evaluation and Mitigation Strategy (REMS) for ipilimumab provides suggestions for when to withhold (Table 1) or permanently discontinue (Table 2) ipilimumab therapy based on the occurrence and severity of irAEs.
"The withholding tables went into effect the day before yesterday," she said.
Another is to change tax withholding tables so that take-home pay would immediately be greater.
The withholding tables would then be reduced just to reflect the diminished tax liability on earnings from that point on.
But the withholding tables cannot be changed until after the tax cut becomes law, probably not before summer.
The Treasury has some discretion over how quickly the tax withholding tables are changed, so some of the tax increases might not be felt for a while.
Treasury officials say the Internal Revenue Service has flexibility to leave the current tax withholding tables in place temporarily, on the assumption there will be some resolution in 2011.
Mr. Grassley said he was leaning toward putting rate cuts into effect retroactive to Jan . 1and ordering the Treasury to develop new withholding tables immediately reflecting lower taxes this year.
But the millions of people who make too little to owe income taxes would get nothing, and putting the new withholding tables in place could take eight weeks or more.
The Internal Revenue Service can delay changing withholding tables for average wage earners if it chooses, on the assumption that their tax cuts will be preserved under any possible compromise, thus forestalling any impact from the fiscal cliff on the vast majority of Americans.
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