Sentence examples for with various specificities from inspiring English sources

Clathrin is a three-legged molecule with a central hub domain from which three ∼190 kDa heavy chains are extended, each ending in an N-terminal seven-bladed β-propeller domain that allows for multiple protein interactions with various specificities between its blades [1].

Systemic lupus erythematosus (SLE) is characterized by polyclonal B-lymphocyte activation, which leads to production of autoantibodies with various specificities, principally against nuclear antigens including double stranded (ds)DNA, ribonucleoprotein particles, histones and nonhistone chromatin proteins.

Its structure was elucidated by peptide mapping with multiple proteases with various specificities (e.g., trypsin, Asp-N, and GluC combined with trypsin or Asp-N) and mass spectrometry with complementary fragmentation modes (e.g., collision-induced dissociation (CID) and electron-transfer dissociation (ETD)).

Ninety-one patients' sera (47.1%) showed autoantibodies of various specificities with a higher incidence of antibodies present in retinopathy patients diagnosed with cancer (33/52; 63.5%; p = 0.009) than in retinopathy patients without cancer (58/141; 41.1%).

Studies in lupus mouse models demonstrated that infiltrating B cells in the kidney secrete antibodies with various Ag specificities, contributing to increased in situ ICs [ 49- 51].

Subsequently we reasoned that a mixture of many different proteases with various substrate specificities might work even better than any single protease.

We believe that the "fluorescent core" of the sensors reported herein may be employed to develop sensors of various specificity with increased dynamic range, allowing reliable quantitative analyses of cellular signaling pathways.

By changing the threshold, various specificity values were obtained.

Before the decision by the FDA to clear the serum HER-2/neu test with a standardized cutpoint of 15 ng/ml, many reports used different research assays with various, uncharacterized antibody specificities, calibrators, and cutoff values to measure circulating HER-2/neu level.

Compared with antibodies, aptamers would be promising recognition elements for bioanalysis because of their high affinity and specificity with various kinds of targets, easy preservation, facile modification, and good stability.

Similarly, CKX enzymes have their own substrate specificity, with various spatial and temporal expression patterns [ 9].