Validation of this result, carried out using the bootstrap technique, after briefly introducing the method, indicates that the resubstitution bias is 1.4%, with a final unbiased performance of about 92%.
In order to assess the unbiased performance of our final SVM classifier, we evaluated its performance on a dataset not used in the training or testing.
This further validates our unbiased, performance-based marker selection approach.
In conclusion, SWang has significant performance with unbiased estimation of skewness and kurtosis under small sample sizes, and is a method to test the differences of the distributions between case and control for complex distribution of microarray data.
He is also concerned with unbiased coverage and although he sometimes writes editorials, they are not critical.
Consequently, together with unbiased sensitivity and specificity estimates, PPV and NPV estimates are unbiased too.
While both criteria coincide with unbiased estimators, there is often no reason to believe that the estimates used are unbiased.
We quantified the contribution of each of the factors to cancer classification and provided unbiased classification performance estimates using established unbiased data analysis protocols.
In order to obtain an unbiased prediction performance, the prediction models should be validated in external data.
In recent years, the field of biomarker discovery has gradually shifted from the aim of finding a single perfect surrogate marker to the construction of composite markers with higher performance, taking advantage of technologies allowing unbiased screening, including microarray analyses.
