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Thus, link (3,10) is removed from the topology to break the interfering chain and links (8,9) and (12,13) are added to set X. Continuing with this loop, all those links are eliminated from the topology which forms interfering chains.
It is certainly noteworthy that BAU binds hUPP1 with this loop in nearly an identical conformation as found in the ligand-free structure, suggesting that this compound binds to a naturally occurring, low-energy state of the enzyme (Figure 3B).
None of the linker residues in the uncomplexed TmPurL interact with this loop.
However, the flavodoxin fingerprint (T/S XTGXT that is normally associated with this loop in flavodoxins is not present in any of the four enzymes.
Interfering with this loop decreases active β-catenin levels, lowers ERK1/2 activity, blocks proliferation, and induces apoptosis in MDA-MB-231, BT474, SkBr3, JIMT-1, and MCF-7 cells.
A third possibility is that the phonological loop used during working memory (Baddeley, Gathercole, & Papagno, 1998) is active during the n-back task for letters, and that the auditory feedback interferes with this loop.
Similar(51)
In the crystal structure of human medium-chain acyl-CoA synthetase in complex with ATP, this loop intimately interacts with the β- and γ-phosphates of the ATP substrate.
In the structures of type II topoisomerases in complex with DNA, this loop (hereafter named DBL for DNA-Binding Loop) constitutes the interface between the Toprim domain and DNA and is stabilized through protein-DNA interactions.
Mutations at position 183 and 185 with Ser in this loop of PK-NCVI/Pk3a NS3 presented almost conserved residues for protease-helicase interaction.
The simulations showed that in the absence of peptide the βII−βIII loop adopted a more open conformation, whereas with peptide bound, this loop quickly adopts a conformation closed around the peptide.
The long helical stem bearing the 12 nt loop is very characteristically predicted in all sequences to be interrupted by at least one bulge at position -4 with regard to this loop (Fig. 6).
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