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Consistent with this, loci on six pig chromosomes became active and more internal during adipogenesis as their chromatin decondenses and 'loops out' from their respective territories (detected using FISH) [ 17].
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Two of the populations were no longer significant after excluding locus Fp92-1 from the analysis, suggesting possible null alleles with this locus.
Importantly, if investigators only analyze rs9939609 in their cohorts of African ancestry, they would miss the association of obesity with this locus, as has already been reported[43].
Although Relish likely contributes to immune function in all species examined, the evolutionary dynamics associated with this locus are dramatically different across lineages.
This screen resulted in the recovery of 27 modifiers, thereby expanding the genetic circuitry of Smn to include several genes not previously known to be associated with this locus.
A very low amount of detectable menin was associated with the previously identified target gene CDKN1B suggesting a cell-type specific role for menin association with this locus [14].
For example, unlike many current tumor markers, such as CA19-9, Cand5 and PSA, which are not truly cancer-specific, the CDKN2A breakpoints are specific and unique for each cancer with this locus deleted.
Furthermore, it remains to be established whether differences in tissue tropism of different parasite strains are due to the MHC haplotype directly or to any other gene selected through linkage disequilibrium with this locus.
However, such assignments suppress uncertainty associated with this locus classification.
All subsequent analyses are presented with this locus removed.
These results strongly support Satb2 as the target of the enhancer activity associated with this locus.
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