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These findings are in line with the "uncoupling to survive" hypothesis proposed by Brand [6], suggesting that uncoupling could be an approach to promote lifespan extension due to its ability to prevent the formation of reactive oxygen species (ROS).
Previous studies have demonstrated that the elevated ADMA levels connected with the uncoupling of NO synthesis contributing to endothelial dysfunction were associated with future cardiovascular events in diabetic patients [ 20].
These fluxes co-occur with the uncoupling of glycolysis from mitochondrial pathways during hypoxia in naïve flies, with glycolysis and pyruvate carboxylation to oxalacetate higher and pyruvate dehydrogenase lower as compared to adapted flies.
In animals, the cellular impact of PAHs has been associated with the uncoupling of mitochondrial respiration, direct genotoxic damages and the formation of reactive oxygen species [ 31, 44- 46].
This STAT3-dependent difference in superoxide generation was also diminished with the uncoupling agent, FCCP, suggesting a dependence on the mitochondrial membrane potential gradient.
Cells were treated with the uncoupling reagent carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and the OPA1 bands were detected by immunoblot.
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Contrasting with this, the uncoupling of the transthylakoidal-ΔpH by NH4Cl did not induce any significant change on the AZ/VAZ.
With digital publishing comes the uncoupling of content from print: why should those six years of work (or more) result in only a physical book that sits on a few shelves?
DCs are exquisitely sensitive to THI, with one mechanism involving the uncoupling of positive and negative regulation of Ca2+ signals contributed by RyR1.
Including the percentage of slow wave coupling, both the temporal regularity and spatial regularity of gastric slow waves have negative correlations with GE, which suggests that the uncoupling may be responsible for the delayed GE in patients with functional dyspepsia [ 82].
Electronic structure calculations and scanning tunneling spectroscopy measurements reveal that the flattening of the graphene layer is linked with the local uncoupling from the metal induced by the increasing oxygen concentration.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com