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Molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) methods [30], in combination with normal-mode analysis (NMODE) [31], were exploited to calculate the free energies of the complexes with the aim to substantiate our kinetic hypothesis and to determine the best enzyme conformation for binding of E1 and NADPH, respectively.
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Deciding just how many is critically dependent on the study aim, with a clear distinction between surveys that aim to substantiate freedom from infection (presence or absence), and those that are designed to provide an estimate of disease prevalence.
We aim to substantiate, with objective arguments, potential advantages of Billroth I simple reconstruction versus Billroth I with semifundoplication.
With the aim to further substantiate the association at the KIAA1109/Tenr/IL2/IL21 gene region, we therefore took advantage of one of the largest reported European family resources dedicated to RA family-based studies.
The study described here aimed to substantiate the model of evolution of genetic redundancy on the basis of the analysis of a ribonuclease family that has contributed to our understanding of some aspects of molecular evolution, such as adaptive evolution [ 6, 7], positive Darwinian selection [ 8], and the origin of retroviruses with long terminal repeats (LTR) [ 9].
> > As these observations point to an unanticipated role of TRa2 in the (patho physiology of TH signaling, we aimed to substantiate the robustness of our strategy.
This study aimed to substantiate the use of the mini-MAC with long-term cancer survivors, by investigating the structure of the scale using Rasch analysis.
This study aimed to substantiate the use of the mini-MAC with long-term cancer survivors, and is the first study to undertake a Rasch analysis of the mini-MAC.
This study aims to substantiate the therapeutic efficacy of γ-EV as an anti-inflammatory agent in a dextran sodium sulphate (DSS -induced colitis porcine moDSS -induced
We aimed to substantiate data on the potential effects of complex insulin injection regimens in this study by looking at how these can affect HRQoL.
The study was designed with the aim to develop a health claim substantiated food ingredient and thus comply with EFSA (European Food Safety authority) requirements [ 9].
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