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With the aim to pick out novel and potent PDK1 inhibitors, herein we report the design and synthesis of a new class of molecules obtained by merging the 2-oxo-indole nucleus with the 2-oxo-pyridonyl fragment, two moieties with high affinity for the PDK1 hinge region and its DFG-out binding site, respectively.
However, with the aim to pick up regulatory motifs present upstream of the transcription start sites our analysis extended the previous one by including 1500 bp sequences instead of 500 bp only.
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These controls aim to pick up the effects of conscription that work through education.
The company aims to pick up where Slide.com (acquired by Google in 2010) left off.
The party hoped to give its vote a fillip by choosing the comic writer John O'Farrell as its candidate and aimed to pick up support from former Liberal Democrat voters disillusioned with the Coalition Government.
"The aim is to pick up as many points from the remaining games that we've got.
The aim: to encourage anyone expanding overseas to pick Ireland for their operations. .
Every year at this time Broadway producers are seized with the urge to pick parents' pockets with splashy holiday fare aimed at young audiences.
It is a user manual, and then some, with the ability to pick out what the camera is being aimed at, and deliver more information on it.
(When Estonians tell it, it's the other way round).Having left Budapest, I am off to Tallinn via Helsinki, with the aim of picking up some news about the impending arrival of the euro (it's now a done deal: Estonia will give up the kroon at the end of the year).
The problem for the visual system is exemplified by the situation of climbing a tree with the aim of picking ripe fruit.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com