The pathogenesis of Alzheimer's disease (AD) is associated with the aggregation of amyloid-β (Aβ) peptides into toxic aggregates with β-sheet character.
By contrast, aggregation inhibitors such as MB interfere with the aggregation process but do not affect de novo synthesis of pro-aggregant toxic Tau.
We conclude that both 6AP and GA interfere with the aggregation process of alanine-expanded PABPN1, eventually leading to the formation of smaller aggregates.
The Wave idea was a centralised communications tool that combined the real-time advantages of Twitter with the aggregation of your email and chat, with collaborative documents too.
We further observed that, p.Val59Met mutation is associated with the aggregation and thus causing HH.
With the aggregation number at hand, the remaining parameters are readily obtained.
With the aggregation and accumulation of mtDNA complete sequences, we tried to conduct founder analysis on whole mtDNA sequences for their high phylogenic resolution.
Previous studies show that NLRP3 mutant patients correlated with the aggregation of NLRP3 into particles with pro-inflammatory extracellular activity that induced the release of ASC specks42.
People conflate business strategy with the aggregation of tactical plans à la Napoleon at Waterloo or Lee at Gettysburg (those geniuses of "military intelligence" also lost, didn't they?).
Our statistical tests show that PAs are formative measures that are consistent with the aggregation method of PA ratings.
The horizontal plane presents equiaxed grains while the vertical plane presents columnar ones with the aggregation of 〈001〉 orientation.
