Indeed, one of the G.M. researchers behind TEL, Thomas Midgley, very nearly poisoned himself while working on the additive, and several workers at a plant experimenting with TEL died gruesome deaths as a result of exposure to it.
Findings from the quantitative studies helped confirm that learning with MIC-O-MAP aids in the development of micro-macro thinking skills whereas the qualitative studies gave rise to specific understanding of how learner interaction with TEL environments can support this development.
In the respiratory inflammation model, the treatment with TEL significantly reduced the BAL levels of TNFα and MIP-2 at 4 hours post endotoxin (Table 1).
As 88% of identified direct target promoters were specific for TEL-AML1 as compared with TEL and AML1 ChIP in this study and very recent AML1 ChIP-seq results, other determinants of binding seem to be involved.
We could, however, not rule out from this assay the possibility of the peptide moieties of these peptolides adopting different conformations influenced by the flexibility of the alkyl-triazolyl moiety, akin to what has been structurally observed with TEL.
