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The crista endings contain moundlike groups of sensory cells with supporting cells; the sensory cells have elongated cilia that are embedded in a gelatinous body, the cupula, which forms a sort of valve across an expanded portion of each semicircular canal.
We encapsulated HepaRG cells, either alone or with supporting cells, in a biodegradable hybrid hydrogel.
Here, we seeded endothelial cells with supporting cells on PLLA/PLGA scaffolds treated with tropoelastin, and examined the morphology, expansion and maturity of the newly formed vessels.
The gastrointestinal (GI) tract is a hollow organ composed of epithelial, muscular, and neural components, along with supporting cells, including interstitial cells of Cajal and endothelial cells, which cooperate to support digestion.
The ECM is known to encode chemotactic, haptotactic, and mechanotactic cues, that are crucial for the control of endothelial cell (EC) migration, and their interaction with supporting cells [ 29, 30].
Together with other structural constituents, proteases and their inhibitors, as well as associated molecules, an ECM microenvironment is created, in which intimate contact of HPCs with supporting cells, such as stellate cells, myofibroblasts and macrophages, occurs [ 2, 3, 6].
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Defined domains of S-layer proteins have been identified as being involved in specific interactions with supporting cell envelope components.
By comparing to each cell lineage from the Jameson et al. study, we could also see that DE genes associated with supporting cell (443), and interstitial cells (210) are represented in our data set at a significant level (Table 2 P-value <0.001).
The models employed NSG mice in combination with allogeneic supporting cells either to reconstitute the human haematopoietic system with cord blood-derived CD34+ stem cells or to supply a component of the microenvironmental stimuli with antigen-presenting CD14+ monocytes.
Here, we show that adult ECs formed vessel networks that were more developed and complex than those formed by human umbilical vein endothelial cells (HUVECs) seeded with various supporting cells on three-dimensional (3D) biodegradable polymer scaffolds.
For instance, our system can be a useful co-culture model of endothelial cells with relevant supporting cells from target sites of metastasis cultured in the bottom channel.
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