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Antibody drugs with superior efficacy have been developed intensively in the last few decades.
The 2003 St. Gallen consensus panel divided the many available adjuvant chemotherapy (CT) regimens into those with "standard efficacy" (AC×4, CMF×6) and those with "superior efficacy" (FA(E C×6, CA(E F×6, A(E →CMF, TAC×6, AC×4→ paclitaxel (P ×4 or docetaxel (D ×4) but also greater complexity, toxicity and cost.
Some examples of the 35 trials classified as "dubious" were: a lamotrigine vs. placebo trial that concluded the active drug "is associated with superior efficacy" although this was true for some but not all analyses [40]; and a trial comparing acetophenazine vs. diazepam in anxious depression that reported several comparisons and was not able to conclude which one was better [41].
Thus, a molecule with superior efficacy is desirable for use an antifibrinolytic agent.
22, 23 Thus, while single agent treatments are effective in reducing MTCT, the development of affordable regimens with superior efficacy and tolerability profiles remains an urgent global priority.
The combination of DHA paclitaxel and carboplatin has the potential to be a regimen with superior efficacy and less toxicity compared to currently used combinations such as paclitaxel carboplatin or docetaxel carboplatin.
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Negro et al. [32] have demonstrated a dose-depending effect of OnaA in patients with CM and medication overuse headache, with a superior efficacy of OnaA 195 U compared to 155 U.
The above cytokine and chemokine analyses showed that IL-17 level in the lungs on day 7 post-challenge was the main immune mediator that correlated with the superior efficacy of the SCHU S4 mutants versus LVS (figure 3).
The latter finding is in line with the superior efficacy of risperidone for coexisting obsessive compulsive symptoms in TS in the study of Gaffney et al. [ 83] as well as in an earlier case report [ 86].
DTG is a once-daily integrase inhibitor that in combination with ABC/3TC, demonstrated superior efficacy with favorable tolerability over TDF/FTC/EFV (SINGLE study) at 48 weeks.
In large phase III trials, irinotecan in combination with 5FU/leucovorin (LV) and oxaliplatin in combination with 5FU/LV showed superior efficacy compared with 5FU/LV alone as first-line therapy (Douillard et al, 2000; Giacchetti et al, 2000; de Gramont et al, 2000; Saltz et al, 2000; Grothey et al, 2002).
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