Nevertheless, this is the first study of its type in the country, with substantial sample size and sufficient time span.
Second, one might argue that the effect sizes of the genetic variants measured here may have been too low to detect even with the substantial sample sizes available to us.
In addition, we acknowledge a need for bigger sample sizes, since complicated models with several parameters require quite substantial sample sizes, as do gene-environment interaction analyses (53, 54).
However, small studies with positive findings are often over-represented in the literature due to publication bias, and substantial sample sizes are needed to detect subtle shifts in the sex ratio.
However, with the substantial sample size and high response rate, the potential biases are minimized.
With a substantial sample size in this study, we also detected minor flux control for CYP83A1 and SUR1, but their influence on overall flux is much less than that caused by CYP79F1.
Although there is an increase in the planned sample size under these designs, due to the sequential nature, substantial sample size reductions compared with the single-stage design is also possible not only in the case of clear efficacy but also in the case of complete lack of efficacy of the new treatment.
Taking into account also the study's substantial sample size, significance tests should be interpreted cautiously and with consideration of effect size.
The substantial sample size of the dataset provided the ability to determine a moderate effect of age at onset with statistical precision.
a A substantial sample size is needed to adequately perform such a correction; b of high importance when assessing motor reaction times with a cognitive task.
Bellenger et al demonstrated substantial sample size reductions (of 81 97%) if CMR measures of volumes, mass and function were serially obtained compared with echocardiography.
