Well, to Graham, an investment wasn't something that could be turned into quick, easy profits; anything that offers such "easy" rewards also comes with substantial risk, and Graham abhorred risk.
CV death, MI, or UA rates were higher in those with prior MI compared with no prior MI (6.68 vs. 2.19; HR 3.04, 95% CI 2.59-3.56) with consistent results for CV death, MI, or UA for rivaroxaban compared with warfarin in prior MI compared with no prior MI (P interaction = 0.10).Prior MI was common and associated with substantial risk for subsequent cardiac events.
In other situations, the isolation may reflect colonisation, but given that colonisation itself is associated with substantial risk of subsequent infection[7] [9] and that there has been a clinical indication for taking a specimen (as opposed to a screen of an otherwise healthy appearing individual), its inclusion in a surveillance measure may be justified.
In florid relapse, however, the efficacy of DLI is limited with substantial risk of severe graft-versus-host disease (GvHD).
Overall, the evidence is sparse and inconclusive due to several low-quality trials with substantial risk of bias and the heterogeneity of examined populations and interventions' [ 18].
For some patients, however, surgery is associated with substantial risk either because of a discharging sinus or proximity of facial nerve branches.
These efforts come with substantial risks for Republicans.
Each of these options is associated with substantial risks and unclear benefits.
Any drug that is injected comes with substantial risks and would face considerable regulatory scrutiny.
Surgery may or may not be effective and, like all surgeries, comes with substantial risks.
Despite the merits of such an idea, a one-off levy is far from an easy solution and comes with "substantial risks," the central bank said.
