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Intensity, proportion and total (i.e. sum of intensity and proportion) IHC scores were reported, including inter-rater variability between pathologists with substantial Quality Assurance experience.
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"You never do anything with people of substantial quality or time.
David Jeary at Investec said the £1bn profit was "unlikely to be a springboard to greater things in the current difficult consumer environment", but added that the group "remains one of the increasingly small handful of retailers with substantial and quality asset backing".
Their approach combines temporal and SNR scalability features with an intelligent packet scheduling strategy to achieve substantial quality gains over convention approaches.
Chronic migraine (CM) affects 2% of the general population with substantial impact on quality of life.
Migraine is a prevalent neurologic disease characterized by severe recurrent headache pain [1] and is associated with substantial functional and quality of life impairments [2].
The disorder is associated with substantial disability, diminished quality of life, impaired physical, social and occupational functioning [2], and poses a challenging treatment problem.
The general health status of the patient will be affected by all of these associated diseases, with substantial impact on quality of life (QoL) [ 33, 74].
Restless legs syndrome (RLS) is a chronic disorder with substantial impact on quality of life similar to that seen in diabetes mellitus or osteoarthritis.
Depression is associated with substantial decreases in quality of life through its impact on physical, social and emotional functioning, and well-being [ 3, 4].
Although urinary incontinence (UI) is a common debilitating and stigmatizing condition with substantial impact on quality of life (QoL), relatively few sufferers seek medical help[ 1].
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