Sentence examples similar to with substantial difficulty from inspiring English sources

Discovery of insertions and deletions smaller than 20 bp is a prevalent part of variant discovery pipelines (GATK, [ 38]) and poses no further challenges to the user, while discovery of indels greater than 20 bp still comes with substantial difficulties.

At 2100 mg BID grade 3 anorexia and a combination of grade 3 anorexia and fatigue yielded protocol-defined DLT in two patients, but because of substantial difficulty with capsule intake experienced by all other patients at this dose, capsule load at 2100 mg BID was considered dose limiting as well, albeit not defined by protocol.

For the higher dimensional situation, one can deal with it in a similar method without substantial difficulty.

It is therefore little wonder that perioperative care providers may have substantial difficulty with do-not-resuscitate (DNR) orders.

All (four) patients in the 2100-mg cohadt had substantial difficulty with the capsule load (seven capsules of 300 mg BID).

Program for Survivors of Torture and Physicians for Human Rights, we found that more than half of the individuals we interviewed with serious health problems reported substantial difficulty in accessing care.

These results show the substantial difficulty associated with the aim of searching for all published cases.

Deficits in abstract thinking can cause patients with schizophrenia to run into substantial difficulties in social interactions during daily life and work life [ 2, 3].

Their preparation can be achieved without substantial difficulties.

Significant advantages are revealed when dealing with problems posing substantial difficulties in keeping diversity, including many-objective problems.

Practical Problems Part of the problem is that extremely low salt diets come with substantial practical difficulties.