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During a ceremony in The Times's newsroom, Bill Keller, the executive editor, told staff members that the Pulitzer board this year had singled out journalism that showed the press "standing up to power, often with substantial consequences".
A rapid change to non fossil energy sources would result in large disruption to the energy supply infrastructure, with substantial consequences for the global economy.
Strong emotions or emotional stress can lead to mental states of depression or anxiety, with substantial consequences on lifestyle and health (73).
Over 90% of fatal crashes occur in low and middle-income countries with substantial consequences, particularly for vulnerable road users such as pedestrians, cyclists, and riders of motorised two-wheelers [ 2- 4].
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This leaves little margin for error in a global economy growing oil demand at 2% annually, raising the chances of an oil supply crisis with more substantial consequences than those seen in the past.
Comorbidities in patients with diabetes are highly prevalent and have substantial consequences for medical expenditures.
17 In conclusion, comorbidities in patients with diabetes are highly prevalent and have substantial consequences for medical expenditures.
An industry bailout of this magnitude is certain to be greeted skeptically by lawmakers from outside the tobacco belt, some of whom will view it as a reward to longtime producers of a product with substantial health consequences.
Yet, there remain large disparities in influenza vaccination rates across elderly Caucasian (70%), African-American (50%) and Hispanic (55%) populations, with substantial mortality consequences.
Although herring bait is also eaten by seals, crabs, fish, sea birds and other benthic fauna, our results suggest that lobsters are significant consumers of bait, with substantial economic consequences.
Symptoms in the Affective cluster (center right) occurred in both individual and group settings with substantial emotional consequences.
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with major consequences
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with substantial impacts
with fundamental consequences
with crucial consequences
with tremendous consequences
with substantial results
with serious consequences
with substantial influences
with substantial effects
with massive consequences
with important consequences
with notable consequences
with substantial impact
with substantial implication
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