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The risk of bias of non-randomized cohort and cross-sectional studies was assessed to be from moderate to serious, and the conclusion of those studies has to be considered with substantial caution when analyzing the findings of the studies included in this systematic review of the literature (see Table 2).
Although interesting, the findings of the study should only be extrapolated to critically ill patients with substantial caution.
Similar(58)
53 The combined cohort relative risk and cross sectional odds ratio should be interpreted with caution, given the substantial heterogeneity detected between studies.
Its results should be interpreted with caution, especially since a substantial proportion of patients may have persistently elevated SUV up to 1 year after treatment without developing local recurrence [ 6].
However, comparison of data from different studies shall be taken with caution since there are substantial methodological variations that may have influenced on the overall HPV positivity, as paraffin-embedded versus fresh-frozen tumors, and on the individual rate of HPV types, obviously driven by the inclusion of type-specific detection probes on the post-PCR hybridization steps.
Our findings should be interpreted with caution since source data had substantial limitations.
Approach with extreme caution.
Proceed with extreme caution.
Only with extreme caution.
Use with extreme caution.
Proceed with great caution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com