Attacks occur in clusters of weeks or months, with subsequent remission periods of months or years.
In agreement with these findings, in 204 acute myeloblastic leukaemia (AML) patients, a high number of cells in S phase related to shorter survival (Vidriales et al, 1995) and a low proportion of G0-phase cells during induction chemotherapy correlated with subsequent remission in AML (Kamikubo et al, 2000).
Consolidation of second or subsequent remission with autologous stem cell transplantation (ASCT) has been shown to be superior to observation in terms of progression-free survival (PFS) and overall survival (OS) in a small, multicenter, randomized trial (Schouten et al. 2003) and is standard practice in some centers.
Patients over 18 years of age with confirmed diagnosis of MDS, AML, ALL, and CML undergoing alloHCT at City of Hope after reaching complete remission (CR) [MDS with ≤20% blasts, AML or ALL in morphologic remission (1st or subsequent remission), or CML in chronic phase] were eligible for the study and were enrolled prospectively.
In patients autografted in first remission, the median number of days with neutropenia (< 0.5 x 10 9) l-1 neutrophils) was 19 (range 9-33) and, in those in subsequent remission, 27 days (range 18-36).
Among patients who did not achieve remission with initial citalopram treatment in the STAR*D trial, approximately one-third of patients augmenting treatment and one-quarter of patients switching antidepressant achieved subsequent remission [ 3].
Optical photons may undergo optical absorption (and subsequent remission via fluorescence), scattering, and refraction or reflection.
The ARFC activity tested in a few patients in subsequent remissions was comparable with controls although functional suppressor activity was increased.
11 All the macular abnormalities were assessed by OCT scans performed at the baseline visit, without considering any subsequent remissions (ie, due to treatment with acetazolamide for CMO).
This implies that the common ways of survival assessment mentioned above are not appropriate for the estimation of the probabilities associated with CML treatment because these measures do not account for the proportion of leukaemia-free patients in subsequent remissions or, conversely, the proportion of patients who have left the remission state.
Positive expression, either if primarily present or later acquired, was associated with melanoma progression, whereas patients primarily negative or with subsequent loss gained clinical remission or stable disease, even if in advanced stages (p < 0.005).
