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Thus, CsA nephrotoxicity is associated with specific alterations in renal AA metabolism.
Alterations in the observable physical form of specific places on chromosomes could be associated with specific alterations in phenotype and heritable alterations in phenotype could be produced by bombarding organisms with high energy radiation ionizing radiation.
Thus, the effects of caloric restriction during gestation on later adiposity and on the differences in the adult phenotype between internal and subcutaneous fat depots in the male offspring may be associated in part with specific alterations in sympathetic innervation, which may impact on WAT architecture.
The circadian behavioral phenotype of HAB mice is associated with specific alterations in clock gene expression in the hippocampus.
EMT induction was associated with specific alterations to the methylation patterns of gene-related CpG-rich regions, although overall methylation levels were not significantly altered.
Collectively, FUS/TLS depletion causes phenotypes possibly related to neuropsychiatric and neurodegenerative conditions, but distinct from ALS and ET, together with specific alterations in RNA metabolisms.
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These changes were associated with region specific alterations in postmortem brain and in periphery, of mRNA and protein expression of three complex I subunits, the 24kDa (NDUFV2), the 51kDa (NDUFV1) and the 75kDa (NDUFsubunitunit, all forming one functional subunit [34].
Cell adhesion was consistently affected in all the analysed samples, both with mutations common to all samples and with shared or sample specific alterations.
Structural connectivity (SC) and FC between supraspinal ROIs to identify specific alterations with DTI 35 between healthy controls and patients with non-neurogenic LUTS (including post-treatment versus pretreatment changes).
Moreover associations of specific alterations with clinical outcome have been described in many pathologies (Lastowska et al., 1997).
The purpose of the meta-analysis is two-fold: on the one hand it identifies a group of genes with overall disease relevance indicating common, tissue-independent processes related to the disease; on the other hand it identifies genes showing specific alterations with respect to a single study.
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