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TCEP is a strong reductant with significant specificity for disulfides [44].
However, in in vitro selection experiments searching for RNA aa-aptamers, it was revealed that RNA could bind an amino acid with significant specificity [ 17- 23].
These findings confirm that the plastid-localized RLSB protein does in fact bind to plastid-encoded rbcL mRNA in vivo, with significant specificity for rbcL mRNA in wild type maize plastids.
Our previous study has shown miR-200c in the blood can distinguish with significant specificity and sensitivity, patients with gastric cancer from healthy controls and remarkably, increased expression levels of miR-200c in blood were significantly associated with poor progression-free and overall survivals in gastric cancer patients [ 21].
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Both human and mouse NEIL1 proteins were found to exhibit a strong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine 2,6-diamino-4-hydroxy-5-formamidopyrimidine 2,6-diamino-4-hydroxy-5-formamidopyrimidine 2,6-diamino-4-hydroxy-5-formamidopyrimidine 2,6-diamino-4-hydroxy-5-formamidopyrimidine 2,6-diamino-4-hydroxy-5-formamidopyrimidine
Endothelial cells (ECs) play a central role in vascularization with two significant specificities: physical interfaces between vascular stroma and blood, and phenotypic organ-specificity.
We further dissected the strength of this association for those orthologs with significant tissue specificity, i.e., those expressed in at least one tissue with p < 1E-6.
Dmknδ5, like Gapex-5, showed no significant specificity towards isoforms.
According to the ROC curve, cutoff levels of 1.51and 3.9 mg/dl were associated with significant change in specificity (Fig. 1).
We have already successfully validated a biomarker panel with significant sensitivity and specificity for more accurately defining pre-operative nodal status in NSCLC, and we hope to bring a similar diagnostic tool into the screening realm (Borgia et al, 2009).
In order not to miss cut-off values with prognostic utility, a Receiver-Operating Curve analysis of IHC staining scores was followed with disease progression as the indicator parameter; this analysis failed to show any cut-off with significant sensitivity and specificity (Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com