Sentence examples for with significant difficulties from inspiring English sources

The protein folding problem remains elusive, with significant difficulties still arising when modeling amino acid sequences lacking an identifiable template.

The administration of local anesthetic before surgery to the great toe is often associated with significant difficulties, delaying surgery and increasing risk.

It is associated with significant difficulties with respect to monitoring.

Patients with significant difficulties in language expression or comprehension were excluded, as were those meeting the exclusion criteria applied to the normal population.

The child was able to grasp objects and bring both hands to the midline, but with significant difficulty.

The trial was as inclusive as possible, but patients requiring urgent assessment, private patients and patients with significant difficulty communicating in English were excluded.

At the 15-year follow-up, 43 (83%) patients could squat normally, 7 (13%) others could do it with slight difficulty and 2 patients (4%) could squat with significant difficulty.

Although in some previous in vitro studies [ 9, 28], the skin was stretched more largely, we selected the stretching amount of 23% because stretching of in vivo forehead skin perpendicular to the body axis more than 23% was with significant difficulty.

Studies concur in finding that females with XXX showed significant difficulties with arithmetic, with around 65% of females finding it difficult.

Children with ADHD experience significant difficulties with emotional regulation and are at greater risk for depression and anxiety [ 43].

1– 4 Prevalence studies indicate that around 13.6% of children with Asperger syndrome (AS) suffer from clinically relevant anxiety 5 and up to 45% of adolescents with AS have significant difficulties with generalised anxiety, social anxiety or specific phobias.