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In the shuffled data, we are unable to identify any miRNA with significant activity change at 0.30 significance level (q<0.30), suggesting a high specificity of our method.
Overall, the results of the study establish 15k as a novel tubulin inhibitor with significant activity against ovarian cancer cells.
As proof-of-the-concept, we show that AApeptides can inhibit p53/MDM2 protein protein interaction with significant activity (IC50 = 38 μM) and specificity.
Biological testing showed that most of the indole-replaced streptochlorin analogues were inactive, though compound 6f had a broad spectrum of antifungal activity with significant activity against Alternaria solani.
An NMR fragment screen for binders to the bromodomains of BRD4 identified 2-methyl-3-ketopyrroles 1 and 2. Elaboration of these fragments guided by structure-based design provided lead molecules with significant activity in a mouse tumor model.
GP-1 is a novel glycoprotein produced by S. kanasenisi ZX01 with significant activity against TMV (Zhang et al. 2015).
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Drawn up by the Labour MP Caroline Flint and supported by more than 60 MPs, the amendment to the finance bill would give the Treasury power to seek more openness on tax from corporations with significant activities in the UK.
Also, compounds with significant activities (MIC < 10 μg/ml) on at least one of the studied organisms include 3, 6, 7 and 8.
Operational stability tests were carried out with selected biocatalysts, with no significant activity loss being observed after 10 consecutive cycles of use and recovery.
A recycling of the catalyst phase was conducted three times with no significant activity loss.
Furthermore, the Mo2N/Al2O3 catalyst exhibits an excellent recycle performance with no significant activity loss after at least three runs.
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