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To investigate further possible reasons for declining selection pressure within Gag epitopes with progression to AIDS, we considered the hypothesis that loss of CD8+ T-cell responses as CD4 count declines results in reversion of escape mutants, with resulting increase in viral replicative capacity.
Activation of the GFAP promoter with resulting increase in synthesis is considered a fundamental property of reactive astrocytes.
While the mechanism cannot be readily probed in the setting of acute human illness, we suspect that that lower BP in AKI may stimulate baroreceptors, with resulting increase in endogenous production of epinephrine, and consequently increased heart rate and kallikrein excretion.
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The current view of regulation of Nrf2 transactivational activity envisages that stimulants stabilize Nrf2 from proteolysis and increased total cellular Nrf2 protein produces equilibrium shift to increased Nrf2 in the nucleus with resulting increased ARE-linked transcription (2).
Unless wages can be depressed further, inflation will eventually rise significantly due to the combined effect of an increase in the money supply and a depreciation of the euro, with resulting increases in import prices – especially of oil and gas.
It does not, for instance, take into account the impact that removing crop residues such as straw can have in depleting the soil's carbon stock, with resulting increases in fertiliser and irrigation use, and lower yields.
These advances in software and operating systems were matched by the development of microprocessors containing ever-greater numbers of circuits, with resulting increases in the processing speed and power of personal computers.
To efficiently cope with resulting increased design complexity, innovative codesign methods are needed to consider the reconfiguration property in the whole system design process.
This spreading is most obvious when it affects the left lateral segments with resulting increased separation of the segment II and III ducts (Fig. 2c).
Pharmacologic thrombolysis also commonly results in longer procedure times, often with prolonged observation required in an intensive care unit with resulting increased procedure-related costs.
We hypothesize that a feed-forward loop exists, with Meq induced CD30 overexpression, constitutive NF-κB activation with resulting increased Meq transcription favoring neoplastic transformation.
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