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Open image in new window Fig. 5 Optimal number of hidden neurons for Model 1-1. Figure 6 shows how the minimum error (hence the optimal model) was attained with respect to the validation and testing during the training process.

Figure 10 also shows the attainment of the optimal model parameters with respect to the least validation error.

Moreover, techniques such as Lasso are far more robust with respect to the cross-validation design in the inner loop of double cross-validation.

Considering only the high confidence calls, the resulting sensitivity with respect to the pre-validation data was 89%.

All sample runs exceeded the high confidence threshold, which resulted in 100% sensitivity with respect to the pre-validation data.

No publications are available with respect to the development and validation of this instrument.

A more thorough investigation of the lifecycle of information models (including their clinical application) should be done with respect to the efficiency of the review process: Are these models invariable for a long time and is therefore an expensive validation process justifiable?

Nevertheless, there is a controversy in the literature with respect to the reliability of double cross-validation under model uncertainty.

The distributions with respect to the key variables were similar in training and validation sets, indicating comparability and suitability for validation.

All interviewers and interpreters of the validation interview were blind with respect to the outcome of the screening interview.

We normalize the calculated area with respect to the maximum of the Hog1PP data in the corresponding validation subset.

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