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With respect to the methodological challenges, applying the SIS for monitoring and decision-making in different contexts and at different scales would be beneficial to gain experiences about the adaptability of the SIS assessment tool and to get valuable clues how to elaborate our approach.
An in-depth analysis of the included publications with respect to the methodological quality (study design, data collection, endpoints chosen) and results showed that none of these publications had adequately investigated the age appropriateness of the medicine for use by older adults.
For our primary analysis using the culture-based DST reference standard, we performed sensitivity analyses for four QUADAS-2 signalling questions to explore whether the results we found were robust with respect to the methodological quality of the studies.
The Study Coordinating Centre has been and remains responsible for monitoring the study execution, particularly with respect to the methodological aspects, ensuring adherence to the study protocol by the collaborating sites and study personnel involved and preparation of summary information and reports.
However, following the idea of qualitative research, we feel that we reached a point of data saturation with respect to the methodological aspects of studies investigating information needs and further studies are unlikely to change our conclusion unless the methodological approaches change.
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Meta-analysis was done to provide a meaningful summary whenever enough studies which were sufficiently similar with respect to the clinical and methodological characteristics were available.
Although all studies can be considered small with respect to the number of patients involved, the methodological quality of the studies can be regarded to be quite high.
With respect to the three meta-analyses, some methodological issues may influence reported outcomes, including selection bias and inadequate consideration of the potential for heterogeneity.
The methodological quality with respect to the rigor of development and implementation of current osteoporosis guidelines is low, although their scores with respect to clinical content are higher.
None of the few previously published twin studies on hip OA using the CTD seems to relate to the methodological weaknesses with respect to the existence of a common environmental component.
With respect to the cross case analysis, all comparative methodological approaches used to study social phenomena must be considered with caution.
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