All the studies were randomised controlled trials in which the researchers were blinded with respect to the assignment (see online supplementary file 2: risk assessment of bias checklist).
Although our analysis and that of Roch et al. [ 14] agree with respect to the assignment of homologs within subfamilies, our results differ in the number of homologs identified, the number of subfamilies named and the order of subfamily origin.
However, models of ancestral eutherian genome organization constructed from such genome sequence alignments display considerable differences with respect to the assignment of ancestral syntenic groups, when compared to models derived from comparative chromosome painting data [ 12, 19, 20, 59].
Separation is obtained by optimizing K-means with respect to the unknown assignment.
With respect to the treatment assignment, the descriptives show that 15% of the establishment observations are treated, implying that 85% of the observations are in the control group of unaffected plants.
The study was double-blind with respect to the treatment assignment.
We found a sensitivity of 99.9%, a positive predictive value (PPV) of 99.7%, and a specificity of 99.9%, with respect to the correct assignment of methicillin resistance.
Then, for each pool P x, i, we define the marginal cost function μ y j, x, P x, i ) with respect to the potential assignment of y j, x to P x, i, as follows.
We then considered the significance of each Gene Ontology (GO [ 24]) category in the "biological process" and "molecular function" ontologies with respect to the known GO assignments to the candidate regulators using the standard hypergeometric distribution test.
The R-O assignment was counterbalanced between-subjects with respect to the R-O assignment in concurrent training stage 1.
