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There is a clear need to find effective treatment options in tinnitus, however, clinical trials differ substantially with respect to methodological quality and design.
Our findings suggest that these metrics may be potential endophenotypes for psychiatric disease and suitable for genetic association studies, but that genetic effects must be interpreted with respect to methodological choices.
This is especially so with respect to methodological and epistemological aspects of Dedekind's work, which ground the logical and metaphysical views that emerge in his writings.
With respect to methodological validation, we found no evidence of bias stemming from differential resource exhaustion by large colonies (Fig. 3B) and that the growth rates of individual colonies measured by our new method were generally comparable to population growth rates in standard batch culture (Fig. 4).
Therefore, results from these studies should be carefully analysed and interpreted with respect to methodological heterogeneity.
With respect to methodological limitations, we have to think of selection bias in our study.
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However, following the idea of qualitative research, we feel that we reached a point of data saturation with respect to the methodological aspects of studies investigating information needs and further studies are unlikely to change our conclusion unless the methodological approaches change.
Also their formalization, although tackled by a number of papers, is not well focused with respect to their methodological usage.
An in-depth analysis of the included publications with respect to the methodological quality (study design, data collection, endpoints chosen) and results showed that none of these publications had adequately investigated the age appropriateness of the medicine for use by older adults.
With respect to the methodological challenges, applying the SIS for monitoring and decision-making in different contexts and at different scales would be beneficial to gain experiences about the adaptability of the SIS assessment tool and to get valuable clues how to elaborate our approach.
Nineteen studies are described with respect to eight methodological criteria.
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