Thus, while FOXP3Δ2Δ7 is able to recruit transcription factors, it is apparently functionally inactive with regard to the suppressor functions commonly linked to FOXP3.
Given the fact that no animal LysM motif-containing genes have been functionally characterized, this study provides clues to functional characterization of plant LysM genes and is also informative with regard to evolutionary and functional studies of animal LysM genes.
The overexpression of MUC1 has been noted in cancer cells with regard to features associated biochemically and functionally (Papadimitriou et al. 1999).
Taken together these results suggest that with regard to transcriptional changes APPα/α is functionally very similar to a complete APP knockout.
The results of this study are particularly interesting in terms of limitations of gene expression profiling with regard to prediction of abundance of functionally active proteins, indicating the need for future studies to investigate potential interference in translational activity and regulation.
Genes were functionally filtered with regard to their association with skeletal development and extracellular matrix formation.
Taken together, these results indicate that naturally arising genetic variation in IL4 residues mapping to the site 1 epitope is functionally neutral with regard to IL4Rα binding and biological signalling.
FMRP, FXR1P or FXR2P can all be specifically displaced from polyribosomes by kcRNA, suggesting that all three family members may be functionally redundant with regard to the regulation of translation of specific mRNAs on polysomes.
This suggests that all three family members recognize the same binding site on RNA mediating their polyribosome association, and that they may be functionally redundant with regard to this aspect of translational control.
This includes rest, adjustment of pain medication, selected injections and nerve ablations for HO associated with neuromata, and multiple attempts at socket modification for amputees, as well as physical therapy for patients in whom HO is functionally limiting with regard to pain or range of movement.
