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The study was approved by the local government (Regierungspraesidium Tuebingen, Germany) with reference number C2/13.
The work is supported by the NSFC project of China (61374041) and the General Research Fund of Hong Kong RGC with reference number 15206717.
These are given below: Figure 5 and Figure 6 should be referenced with reference number 53 from the reference list in [1].
The study was approved by the Ethics Committee of the Saarland Physicians Council (Ärztekammer des Saarlandes, application with reference number Ha06/08).
The adult case control cohort was approved by the Swedish regional ethics review board in Umeå with reference number 321/03, diary nr 03-285.
All procedures involving laboratory animals were approved by the regional animal ethics review board in Gothenburg, Sweden with reference number 366-2005.
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All animal experiments with reference numbers #14‒054, #15 085, and #16 003 were approved by the Animal Care and Use Committee of the Korea Institute of Oriental Medicine (KIOM, Daejeon, Korea) and were performed in accordance with their guidelines.
First, cage molecules were constructed for each cage isomer combination using the crystallographic structure of cage 1 as a template (obtained from the Cambridge Crystallographic Database with reference numbers CCDC 707056 21.
Atomic coordinates, thermal parameters and bond lengths and angles have been deposited at the Cambridge Crystallographic Data Centre (CCDC) with reference numbers 1463766 and 1463767.
Ethical approval was obtained for all patient collections and human research from the Women's and Children's Hospital (Adelaide) Research Ethics Committee with reference numbers REC1262/11/2004 & REC1340/6/2005.
All experimental procedures were approved by the Regional Ethical Committee at the Uppsala University Hospital (Regionala etikprövningsnämnden i Uppsala), with reference numbers 2004:M-223 (Hepatocytes) and 2009/152 (Carcinoids).
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