Sentence examples for with reduced potency from inspiring English sources

Exact(9)

But then again, few other world leaders are exclusively surrounded, as Pope Francis is, by men (many of them elderly, though I wouldn't dream of suggesting that means they are people with reduced potency or lack of energy).

Efficacy may be achieved with reduced potency against individual targets if there is synergy through multiple pathway inhibition.

They found that aldosterone retained its activity as an agonist, although with reduced potency.

CGRP also activates AM1 and AM2 receptors although with reduced potency compared to AM (McLatchie et al., 1998).

While lamprey insulin accelerated the dissociation of I-labeled human insulin, albeit with reduced potency, the data suggest a lack of reversal with increasing concentrations of unlabeled ligand.

Results shown in Figures  4 and 5 illustrated that JAK2 is also targeted by GNF-2, however, with reduced potency, consistent with the presence of a myristate binding pocket (MBP) within the JAK2 kinase (data not shown).

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Similar(50)

Potency of AMG 334 at the cyno CGRP receptor is similar to that at the human receptor, but with significant reduced potency at dog, rabbit and rat receptors.

Addition of γ-wt to A3.01 cells (upper panel) or primary CD4+ T lymphocytes (lower panel) confirmed, in agreement with previous findings [33], the reduced potency of γ-wt as compared to α-wt regarding chemotactic activity.

On the other hand, Chung and Champagne [17] found that phytic acid formed insoluble complexes with the major peanut allergens, resulting in peanut extract with reduced allergenic potency and suggested that phytic acid may find its use in the development of hypoallergenic peanut-based products.

Additional studies are necessary to investigate whether the reduced potency of Halα mutants in combination with wild-type Halβ is reflective of the ability of Halα mutants to bind lipid II, to effectively recruit Halβ for synergistic activity, or both.

The AspB10His analogue had the most reduced potency of all the analogues, in accordance with the relative affinity described in Table 3. Hagfish, HisA8Thr, and AspA15Gln insulin had almost identical potencies, HisA8Thr having the most reduced potency.

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