Sentence examples for with reduced efficacy from inspiring English sources

Along similar lines, regions of highly reduced recombination in the Drosophila genome exhibit elevated levels of nonsynonymous polymorphism, consistent with reduced efficacy of selection in these regions (Presgraves 2005; Betancourt et al. 2009).

In addition, headaches recur within a predictable period after the last dose of medication, usually with reduced efficacy.

The British study also suggested that the number of days with reduced efficacy was around four times higher than the number of days missed.

Immediate vaccination with a non-clade matched vaccine, even with reduced efficacy, would prevent thousands of new infections in SF and millions in SA over 30 years.

While this single activity may lead to suboptimal radiation doses in neuroendocrine tumors (NET) with advanced or bulky disease, dose escalation has been withheld due to concerns on potential tumor somatostatin receptor saturation with reduced efficacy of the added activity.

We utilized a mathematical model to determine the effectiveness of immediate roll-out of a non-clade matched vaccine with reduced efficacy compared to constructing clade specific vaccines, which would take considerable time to manufacture and test in safety and efficacy trials.

Although liposome entrapment of antibiotics and their increased efficacy is not a novel finding, neutral liposome-entrapped antibiotics tended to be more bactericidal in sputum and in the presence of sputum components when compared to free antibiotics, but with reduced efficacies over a longer period of time in vitro (18 h exposure).

Although the profile of this signature was very similar between EGF- and HPX-stimulated MDA-MB-468 cells, several of the transcripts showed a greater degree of upregulation with hypoxia, in agreement with the reduced efficacy of AZD6244 within hypoxia-stimulated MDA-MB-468 cells (Table  3b).

They demonstrate that overexpression of ANGPTL2 is associated with a reduced efficacy of 5-FU and with an upregulation of antiapoptotic cell signaling molecules, such as BCL-2 and BCL-XL.

In mice treated with 1 mg/ml micafungin, cysts with typical morphologies were apparent (Panel i, arrow), which coincided with the reduced efficacy at this dose.

In summary, our results suggest that KRAS mutations could be associated with the reduced efficacy of definitive CRT and a shortened survival time in patients with stage III non-squamous NSCLC.